to 5000 rads.Although the natural history of anal intraepithelial neoplasia is not yet clearly defined, it is possible that adequate treatment and follow-up in his case may have prevented the malignant transformation.This case emphasises firstly, the need to ensure adequate treatment and follow-up in such cases to prevent this complication and secondly, to perform biopsies in those who have recalcitrant or atypical warts.
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Frank et al. (1996) studied this question.
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