Antibody-Forming Cells: Population Patterns after Simultaneous Immunization with Different Isoantigens

Spleen cells were obtained from chickens stimulated simultaneously with different erythrocytic antigens, and the proportions producing one and two antibodies were determined by the hemolytic-plaque technique. Most cells from birds immunized with two antigens of the same system (B) appeared to produce only one antibody. In a population of cells from birds immunized with antigens of different systems (A and B), a relatively high proportion of cells produced two antibodies.