Key result
Electroacupuncture at Zusanli points significantly reduced CK-MB, TNF-α, NO, MPO, and water content compared to sham acupuncture in septic rats at 6 hours.
Why the study?
Does electroacupuncture at Zusanli points reduce myocardial injury in a rat model of sepsis?
RCT (n=48)
Randomly divided
Does electroacupuncture at Zusanli points reduce myocardial injury in a rat model of sepsis?
Electroacupuncture at Zusanli points reduces myocardial injury and inflammation in septic rats, likely mediated through the cholinergic anti-inflammatory pathway.
Hypothesis-generating in septic rats; leaves open translation to human myocardial protection.
The protective effect of electroacupuncture (EA) at Zusanli points (ST36) on myocardial injury in a model of sepsis was observed. Forty‐eight male Sprague‐Daley rats were subjected to sepsis by cecal ligation and puncture (CLP) and randomly divided into 4 groups (n=12; A: sepsis + EA; B: sepsis + sham acupuncture; C: sepsis + vagotomy; D: sepsis + vagotomy + EA). Bilateral points were stimulated (2mA, 2‐100 Hz) for 1 hour. Abdominal vagotomy was performed in groups C and D. At 6h after CLP, the plasma activity of creatine kinase‐MB (CK‐MB) was determined. A part of cardiac muscle was harvested for evaluating levels of tumor necrosis factor (TNF‐ α ), nitric oxide (NO), myeloperoxidase (MPO), and the rate of water content. The activities of CK‐MB, TNF‐ α , NO, and MPO and the rate of water content in group A were significantly lower than those of the other groups 6h after CLP. EA after vagotomy showed less anti‐inflammatory and protective effects. The results indicated that EA obviously reduced the increased levels of the proinflammatory factors at 6h after CLP, and vagotomy could weaken or eliminate the effects of EA. Cholinergic anti‐inflammatory pathway is one of the main mechanisms of cardioprotective effect of EA.
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Zhang et al. (2018) conducted an RCT in Sepsis with myocardial injury (n=48). Electroacupuncture at Zusanli points (ST36) vs. Sham acupuncture, vagotomy, or vagotomy plus electroacupuncture was evaluated on Plasma activity of CK-MB, TNF-α, NO, MPO, and rate of water content at 6 hours after cecal ligation and puncture. Electroacupuncture at Zusanli points significantly reduced CK-MB, TNF-α, NO, MPO, and water content compared to sham acupuncture in septic rats at 6 hours.
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