Miniaturized green sample preparation approaches for pharmaceutical analysis

The development of green sample preparation procedures is an extremely important research field in which more and more applications are constantly being proposed in different areas, including pharmaceutical analysis. This review article is aimed at providing a general overview of the development of miniaturized green analytical sample preparation procedures in the pharmaceutical analysis field, with special focus on the works published between January 2017 and July 2021. Particular attention has been paid to the application of environmentally friendly solvents and sorbents as well as nanomaterials or high extraction capacity sorbents in which the solvent volumes and reagents amounts are drastically reduced, with their subsequent advantages from the sustainability point of view.