Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database

// Juan Zhou 1, * , San-Gang Wu 2, * , Jia-Yuan Sun 3, * , Li-Ying Tang 4 , Huan-Xin Lin 3 , Feng-Yan Li 3 , Qiong-Hua Chen 1 , Xin Jin 5 and Zhen-Yu He 3 1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China 2 Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China 3 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China 4 Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College of Xiamen University, Xiamen, People’s Republic of China 5 Faculty of Basic Medicine, Medical College, Xiamen University, Xiamen, People’s Republic of China * These authors have contributed equally to this work Correspondence to: Xin Jin, email: xinjin@xmu.edu.cn Zhen-Yu He, email: hezhy@sysucc.org.cn Keywords: cervical carcinoma, small cell, survival, prognosis Received: June 06, 2016     Accepted: March 03, 2017     Published: March 21, 2017 ABSTRACT To investigate the clinicopathological characteristics and survival of small cell carcinoma of the cervix using Surveillance, Epidemiology, and End Results database. Patients with a diagnosis of small cell carcinoma of the cervix were included between 1988 and 2012. Kaplan-Meier method and Cox regression models were used. A total of 487 patients were included. Of the patients with known International Federation of Gynecology and Obstetrics stage and tumor grade, the stage IV disease was diagnosed in 37.9% patients, and 98.5% patients had poorly or undifferentiated histology. The 5-year cause specific survival and overall survival were 33.0% and 29.4%, respectively. In multivariate analysis, increasing age, advanced stage, and treatment by primary radiotherapy were associated with worse survival outcomes. Small cell carcinoma of the cervix is a rare disease with aggressive characteristics and prone to metastasize and is dismal in prognosis. Reduced survival was associated with increasing age, advanced stage, and treatment by primary radiotherapy.