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Clinical Staff Conference1 October 1964Humoral Syndromes Associated with Nonendocrine TumorsMORTIMER B. LIPSETT, M.D., F.A.C.P., WILLIAM D. ODELL, M.D., LEON E. ROSENBERG, M.D., THOMAS A. WALDMANN, M.D.MORTIMER B. LIPSETT, M.D., F.A.C.P.Search for more papers by this author, WILLIAM D. ODELL, M.D.Search for more papers by this author, LEON E. ROSENBERG, M.D.Search for more papers by this author, THOMAS A. WALDMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-733 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Mortimer B. Lipsett: During the past 10 years, the oncologist and endocrinologist have become increasingly aware of the occurrence of several endocrine syndromes in association with neoplasia. There is presumptive evidence in each case that the syndrome is due to overproduction of a hormone or a hormonal-like material synthesized by a neoplasm arising from tissue that does not normally produce the hormone.The syndromes that have been described are presented in Table 1 with an estimate of the number of cases of each that has been reported. The hormonal-like activity that has been either demonstrated or inferred in each...References1. GREENSTEIN JP: Biochemistry of Cancer, Academic Press, New York, 1947. Google Scholar2. DE GENNESBRICAIRELEPRAT LHJ: Les syndromes endocriniens paraneoplasiques. II. Hyperthyroides et endocrinopathies diverses. Presse Med. 70: 2137, 1962. MedlineGoogle Scholar3. ODELLBATESRIVLINLIPSETTHERTZ WDRWRSMBR: Increased thyroid function without clinical hyperthyroidism in patients with choriocarcinoma. J. Clin. Endocr. 23: 658, 1963. CrossrefMedlineGoogle Scholar4. STEIGBIEGELOPPENHEIMFISHMANCARBONE NJLP: Metastatic embryonal carcinoma of the testis associated with elevated plasma TSH-like activity and hyperthyroidism. New Eng. J. Med. 271: 345, 1964. CrossrefMedlineGoogle Scholar5. HERTZLEWISLIPSETT RJMB: Five years' experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer. J. Obstet. Gynec. 82: 631, 1961. CrossrefMedlineGoogle Scholar6. NADLERWOLFER WHJA: Hepatogenic hypoglycemia associated with primary liver cell carcinoma. Arch. Intern. Med. (Chicago) 44: 700, 1929. CrossrefGoogle Scholar7. MCFADZEANYOUNG AJTT: Hypoglycemia in primary carcinoma of the liver. Arch. Intern. Med. (Chicago) 98: 720, 1956. CrossrefGoogle Scholar8. KLEINKLEIN HSP: Spontaneous hypoglycemia associated with massive hepatoma. Arch. Intern. Med. (Chicago) 103: 272, 1959. Google Scholar9. CRAWFORD W: Hypoglycemia with coma in a case of primary carcinoma of the liver. Amer. J. Med. Sci. 181: 496, 1931. CrossrefGoogle Scholar10. SCHONFELDBABBOTTGUNDERSEN ADK: Hypoglycemia and polycythemia associated with primary hepatoma. New Eng. J. Med. 265: 231, 1961. CrossrefMedlineGoogle Scholar11. LANDAUWILLSCRAIGLEONARDSMORIWAKI BRNJWJRT: The mechanism of hepatoma-induced hypoglycemia. Cancer 15: 1188, 1962. CrossrefMedlineGoogle Scholar12. AUGUSTHIATT JTHH: Severe hypoglycemia secondary to a nonpancreatic fibrosarcoma with insulin activity. New Eng. J. Med. 258: 17, 1958. CrossrefMedlineGoogle Scholar13. MILLERBOLINGERJANIGANCROCKETTFRIESEN DRREDJESR: Hypoglycemia due to nonpancreatic mesodermal tumors. Ann. Surg. 150: 684, 1959. CrossrefMedlineGoogle Scholar14. SILVERSTEINWAKIMBAHNBAYRD MNKGRCED: A hypoglycemic factor in leukemic tumors. Proc. Soc. Exp. Biol. Med. 103: 824, 1960. CrossrefMedlineGoogle Scholar15. LAGERSORSDUBOSTMAGDELAINELEJEUNEROSEAULEMAGNE LCCMJEG: Hypoglycemia due to extrapancreatic mesenchymal tumors. Presse Med. 71: 219, 1963. MedlineGoogle Scholar16. BRUNOOBER MSWB: Hypoglycemia and an intrathoracic mass. New York J. Med. 62: 2005, 1962. Google Scholar17. HAYESSPURRFELTSMILLER DMCLJHEC: Von Bechlinghausen's disease with massive intra-abdominal tumor and spontaneous hypoglycemia. Metabolism 10: 182, 1961. Google Scholar18. BOSHELLKIRSCHENFELDSOTERES BRJJPS: Extrapancreatic insulin-secreting tumor. New Eng. J. Med. 270: 338, 1964. CrossrefMedlineGoogle Scholar19. PETERSONLUNDRINGSTED JRJ: Hypoglycemia in the presence of massive fibrosarcoma. Acta Endocr. 34: 148, 1960. MedlineGoogle Scholar20. NEVIUSFRIEDMAN DBNB: Mesotheliomas and extraovarian thecomas with hypoglycemic and nephrotic syndromes. Cancer 12: 1263, 1959. CrossrefMedlineGoogle Scholar21. STAUFFERGRANVILLELAW JNGESW: Recurrent hypoglycemia and retroperitoneal fibrosarcoma. New Eng. J. Med. 265: 979, 1961. CrossrefMedlineGoogle Scholar22. OLEESKYBAILEYSAMOLSBILKUS JIED: A fibrosarcoma with hypoglycemia and a high serum insulin level. Lancet 2: 378, 1962. CrossrefMedlineGoogle Scholar23. KEEN H: Fluctuating hyper- and hypoglycaemia associated with multiple hepatic tumours. Guy Hosp. Rep. III: 200, 1962. Google Scholar24. VOLKGOLDNERWAINFELD BWMGB: Spontaneous hypoglycemia with abdominal spindle-cell sarcoma. Geriatrics 15: 473, 1960. MedlineGoogle Scholar25. BEERSMORTON DNJJ: Primary carcinoma of the liver with hypoglycemia. Amer. J. Cancer 24: 51, 1935. CrossrefGoogle Scholar26. SECKEL HP: Postmortem hepatic glycogenolysis in hyperinsulinism and glycogen disease. J. Clin. Invest. 18: 723, 1939. CrossrefMedlineGoogle Scholar27. SCHOLZWOOLNERPRIESTLEY DALBJT: Spontaneous hypoglycemia associated with fibrogenic tumor. Ann. Intern. Med. 46: 796, 1957. LinkGoogle Scholar28. GARFIELDBELCHERSHUTTLEWORTH CRHVJS: Fibrous mesothelioma with hypoglycemic psychosis. JAMA 181: 380, 1962. CrossrefMedlineGoogle Scholar29. HOWARDDAVIS JNPL: Retroperitoneal hemangiopericytoma associated with hypoglycemia and masculinization. Delaware Med. J. 31: 29, 1959. MedlineGoogle Scholar30. WHITNEYMASSEY JC: Apparent insulin activity in a fibrosarcoma associated with spontaneous hypoglycemia. J. Clin. Endocr. 21: 541, 1961. CrossrefGoogle Scholar31. FIELDKEENJOHNSONHERRING JBHPB: Insulin-like activity of non-pancreatic tumors associated with hypoglycemia. J. Clin. Endocr. 23: 1229, 1963. CrossrefGoogle Scholar32. TRANGUADABENDERBEIGELMAN REABPM: Hypoglycemia associated with carcinoma of the cecum and syndrome of testicular feminization. New Eng. J. Med. 266: 1302, 1962. CrossrefMedlineGoogle Scholar33. MURPHY R: Hypoglycemia associated with an extrapancreatic neoplasm. Med. Clin. N. Amer. 47: 391, 1963. CrossrefMedlineGoogle Scholar34. GONZALEZGOLDSCHNEIDER FMGLBL: Gastrointestinal carcinoma and concomitant hypoglycemia. Ann. Intern. Med. 58: 149, 1963. LinkGoogle Scholar35. BARTONLABAUGE PR: Les tumerus mesenchymateuses hypoglycemiantes. Presse Med. 69: 2635, 1961. MedlineGoogle Scholar36. SELLMANPERKOFFNULLKIMMELTYLER JCGTFCJRFH: Hypoglycemia associated with massive intra-abdominal mesothelial-cell sarcoma. New Eng. J. Med. 260: 847, 1959. CrossrefMedlineGoogle Scholar37. SILVERSTEINWAKIMBAHNBAYRD MNKGRCED: Additional preliminary observations on the hypoglycemic factor. Proc. Mayo Clin. 37: 95, 1962. MedlineGoogle Scholar38. DAMONHOLUBMELICOWUSON ADAMMAC: Polycythemia and renal carcinoma. Amer. J. Med. 25: 182, 1958. CrossrefMedlineGoogle Scholar39. GURNEY CW: Erythremia in renal disease. Trans. Ass. Amer. Physicians 73: 103, 1960. MedlineGoogle Scholar40. HEWLETTHOFFMANSENHAUSERBATTLE JSGCDAJD: Hypernephroma with erythrocythemia: report of a case and assay of the tumor for an erythropoietic stimulating substance. New Eng. J. Med. 262: 105, 1960. CrossrefMedlineGoogle Scholar41. KORSTFRENKELCOUSINEAUMUIRHEAD DREPLEE: Erythropoietin studies in human renal abnormalities. Correlative renal explant attempts in the rat and dog, in Erythropoiesis, edited by JACOBSON, L. O., DOYLE, M., Grune & Stratton, New York, 1962, p. 374. Google Scholar42. ROSSEWALDMANNCOHEN WFTAP: Renal cysts, erythropoietin and polycythemia. Amer. J. Med. 34: 76, 1963. CrossrefMedlineGoogle Scholar43. CARPENTERSCHWARTZWALKER GHGAE: Neurogenic polycythemia. Ann. Intern. Med. 19: 470, 1943. LinkGoogle Scholar44. WALDMANNLEVINBALDWIN TAEHM: The association of polycythemia with a cerebellar hemangioblastoma: The production of an erythropoiesis stimulating factor by the tumor. Amer. J. Med. 31: 318, 1961. CrossrefMedlineGoogle Scholar45. THOMSONMARSON APFG: Polycythemia with fibroids. Lancet 2: 759, 1953. CrossrefGoogle Scholar46. MCFADZEANTODDTSANG AJDKC: Polycythemia in primary carcinoma of the liver. Blood 13: 427, 1958. CrossrefMedlineGoogle Scholar47. WALDMANNBRADLEY TAJE: Polycythemia secondary to a pheochromocytoma with production of an erythropoiesis-stimulating factor by the tumor. Proc. Soc. Exp. Biol. Med. 108: 425, 1962. CrossrefGoogle Scholar48. WARDFOLTZKNOPP AAELLM: "Polycythemia" associated with cerebellar hemangiogblastoma. J. Neurosurg. 13: 248, 1956. CrossrefMedlineGoogle Scholar49. FRIEDPLZAKJACOBSONGOLDWASSER WLLOE: Erythropoiesis. II. Assay of erythropoietin in hypophysectomized rats. Proc. Soc. Exp. Biol. Med. 92: 203, 1956. CrossrefMedlineGoogle Scholar50. ROSSEWALDMANNHOUSTON WFTADE: Erythropoietin assays using Iron59 incorporation into blood and spleen of the polycythemic mouse. Proc. Soc. Exp. Biol. Med. 109: 836, 1962. CrossrefMedlineGoogle Scholar51. ROSSEBERRYWALDMANN WFRJTA: Some molecular characteristics of erythropoietin from different sources determined by inactivation of ionizing radiation. J. Clin. Invest. 42: 124, 1963. CrossrefMedlineGoogle Scholar52. ROSSEWALDMANN WFTA: Molecular similarities in erythropoiesis stimulating factors (erythropoietins) from various sources. Ibid., p. 972. Google Scholar53. LEA DE: Actions of Radiations on Living Cells, 2nd edition, Cambridge University Press, London, 1955. Google Scholar54. JACOBSONGOLDWASSERFRIEDPLZAK LOEWL: Role of the kidney in erythropoiesis. Nature (London) 179: 633, 1957. CrossrefMedlineGoogle Scholar55. KURATOWSKALEWATOWSKIMICHALAK ZBE: Studies on the production of erythropoietin by the isolated hypoxic kidney. Bull. Acad. Pol. Sci. [Biol.] 8: 77, 1960. Google Scholar56. ROSSEWALDMANN WFTA: The role of the kidney in the erythropoietic response to hypoxia in parabiotic rats. Blood 19: 75, 1961. CrossrefGoogle Scholar57. WOODARD HW: Changes in blood chemistry associated with carcinoma metastatic to bone. Cancer 6: 1219, 1953. CrossrefMedlineGoogle Scholar58. SWYERBERGERGORDONLASZLO AJJSHMD: Hypercalcemia in osteolytic metastatic cancer of the breast. Amer. J. Med. 8: 724, 1950. CrossrefMedlineGoogle Scholar59. MYERS WP: Hypercalcemia in neoplastic disease. Cancer 9: 1135, 1956. CrossrefMedlineGoogle Scholar60. PEARSONWESTHOLLANDERTREVES OHCDVPNE: Evaluation of endocrine therapy for advanced breast cancer. JAMA 154: 234, 1953. CrossrefGoogle Scholar61. KLEMPERER P: Parathyroid hyperplasia and bone destruction in generalized carcinomatosis. Surg. Gynec. Obstet. 36: 11, 1923. Google Scholar62. ALBRIGHTREIFENSTEIN FEC: The Parathyroid Glands and Metabolic Bone Disease—Selected Studies, Williams and Wilkins, Baltimore, 1948. Google Scholar63. CONNORTHOMASHOWARD JBWCJE: The etiology of hypercalcemia associated with lung carcinoma. J. Clin. Invest. 35: 697, 1956. Google Scholar64. PLIMPTONGELLHORN CHA: Hypercalcemia in malignant disease without evidence of bone destruction. Amer. J. Med. 21: 750, 1956. CrossrefMedlineGoogle Scholar65. ALANISFLANAGAN BFJF: Myopathy and hypercalcemia occurring with carcinoma of the kidney. JAMA 171: 2076, 1959. CrossrefMedlineGoogle Scholar66. CASE RECORDS, New Eng. J. Med. 264: 242, 1961. CrossrefMedlineGoogle Scholar67. CASE RECORDS, New Eng. J. Med. 265: 953, 1961. CrossrefGoogle Scholar68. DAVIDVERNERENGEL NJJVFL: The diagnostic spectrum of hypercalcemia. Amer. J. Med. 33: 88, 1962. CrossrefMedlineGoogle Scholar69. CASE RECORDS, New Eng. J. Med. 256: 750, 1957. CrossrefMedlineGoogle Scholar70. GOLDSHNIDER GLBI: Some unusual syndromes associated with neoplastic disease. Ann. Intern. Med. 51: 890, 1959. LinkGoogle Scholar71. CAREY VC: Hypercalcemia and bronchial carcinoma. Amer. Rev. Resp. Dis. 85: 258, 1961. Google Scholar72. MASSAROOWEN DJJA: Persistent hypercalcemia associated with bronchogenic carcinoma and primary chief cell hyperplasia of the parathyroids. Ibid., p. 727. Google Scholar73. ABOUAVBERKOWITZKOLB JSBFO: Reversible hypercalemia in masculinizing hypernephroid tumor of the ovary. New Eng. J. Med. 260: 1057, 1959. CrossrefMedlineGoogle Scholar74. BREIDAHLRITCHIE HDBC: Hypercalcemia due to malignant ovarian tumor. Med. J. Aust. 1: 208, 1962. CrossrefGoogle Scholar75. LUCAS PF: Acute hypercalcemia from carcinomatosis without bone metastases. Brit. Med. J. 1: 1330, 1960. CrossrefMedlineGoogle Scholar76. MAGNENATPERRET VPC: Carcinoma of the pancreas with hypercalcemia. Gastroenterologia (Basel) 96: 197, 1961. MedlineGoogle Scholar77. LOEBELWOLKOFF ASCS: Hypercalcemia in neoplastic disease without bone metastases. New York J. Med. 62: 101, 1962. MedlineGoogle Scholar78. CASE RECORDS, New Eng. J. Med. 248: 248, 1953. CrossrefMedlineGoogle Scholar79. SCHATTENSHIPPIEPERBARTTER WEAGWJFC: Syndrome resembling hyperparathyroidism associated with squamous cell carcinoma. Ann. Surg. 148: 890, 1958. CrossrefMedlineGoogle Scholar80. SAMUELSSONWERNER SMI: Hepatic carcinoma simulating hyperparathyroidism. Acta Med. Scand. 173: 539, 1963. CrossrefMedlineGoogle Scholar81. CASE RECORDS, New Eng. J. Med. 269: 801, 1963. CrossrefMedlineGoogle Scholar82. THOMASCONNORMORGAN WCTBHG: Some observations on patients with hypercalcemia exemplifying problems in differential diagnosis especially in hyperparathyroidism. J. Lab. Clin. Med. 52: 11, 1958. MedlineGoogle Scholar83. REISSALEXANDER EP: The tubular reabsorption of phosphate in the differential diagnosis of metabolic bone disease. J. Clin. Endocr. 19: 1212, 1959. CrossrefGoogle Scholar84. WALSER M: The separate effects of hyperparathyroidism, hypercalcemia of malignancy, renal failure and acidosis on the state of calcium, phosphate and other ions in plasma. J. Clin. Invest. 41: 1454, 1962. CrossrefMedlineGoogle Scholar85. BENTZELCARBONEROSENBERG CPLE Effect of prednisone on calcium balance and Ca47 kinetics in patients with multiple myeloma and hypercalcemia. J. Clin. Invest. (In press). Google Scholar86. TASHJIANLEVINEMUNSON AHLPL: Immunochemical identification of parathyroid hormone in nonparathyroid neoplasms associated with hypercalcemia. J. Exp. Med. 119: 467, 1964. CrossrefMedlineGoogle Scholar87. TASHJIANLEVINEMUNSON AHLPL: Immunoassay of parathyroid hormone by quantitative complement fixation. Endocrinology 74: 244, 1964. CrossrefMedlineGoogle Scholar88. WILSONMERRICKWOODWARD JRHER: Hypercalcemia simulating hyperparathyroidism induced by XV-2 carcinoma of rabbit. Ann. Surg. 154: 485, 1961. CrossrefMedlineGoogle Scholar89. BROWN WH: A case of pluriglandular syndrome: "diabetes of bearded women." Lancet 2: 1022, 1928. CrossrefGoogle Scholar90. LEYTONTURNBULLBRATTON OAMAB: Primary cancer of the thymus with pluriglandular disturbance. J. Path. Bact. 34: 635, 1931. CrossrefGoogle Scholar91. ALLOTTSKELTON NEMO: Increased adrenocortical activity associated with malignant disease. Lancet 2: 278, 1960. CrossrefMedlineGoogle Scholar92. KRACHTHUNTSCHMANN JN: Tumor syntropien des Cushing-syndroms. Acta Endocr. 38: 490, 1961. MedlineGoogle Scholar93. HYMESDOE ACRP: Adrenal function in cancer of the lung, with and without Cushing's syndrome. Amer. J. Med. 33: 398, 1962. CrossrefMedlineGoogle Scholar94. WILLIAMSISLANDOLDFIELDLIDDLE WCDRAGW: Blood corticotropin (ACTH) levels in Cushing's disease. J. Clin. Endocr. 21: 426, 1961. CrossrefMedlineGoogle Scholar95. MEADORLIDDLEISLANDNICHOLSONLUCASNUCKTONLUETSCHER CKGWDPWECPJGJA: Cause of Cushing's syndrome in patients with tumors arising from non-endocrine tissue. J. Clin. Endocr. 22: 693, 1962. CrossrefMedlineGoogle Scholar96. LIDDLE GW: Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J. Clin. Endocr. 20: 1539, 1960. CrossrefMedlineGoogle Scholar97. PRUNTYBROOKSDUPREGIMLETTEHUTCHINSONMCSWINEYMILLS FTRSJTMJSRRIH: Adrenocortical hyperfunction and potassium metabolism in patients with "non-endocrine" tumors and Cushing's syndrome. J. Clin. Endocr. 23: 737, 1963. CrossrefMedlineGoogle Scholar98. LIDDLEISLANDNEYNICHOLSONSHIMIZU GWDPRLWEN: Nonpituitary neoplasms and Cushing's syndrome. Arch. Intern. Med. (Chicago) 111: 471, 1963. CrossrefMedlineGoogle Scholar99. BROOKSDUPREGOGATEMILLSPRUNTY RVJANIHFT: Appraisal of adrenocortical hyperfunction: Patients with Cushing's syndrome or non-endocrine tumors. J. Clin. Endocr. 23: 725, 1963. CrossrefGoogle Scholar100. SCHWARTZBENNETTCURELOPBARTTER WBWSFC: Syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Amer. J. Med. 23: 529, 1957. CrossrefMedlineGoogle Scholar101. AMATRUDAMULROWGALLAGHERSAWYER TTPJJCWH: Carcinoma of the lung with inappropriate antidiuresis. New Eng. J. Med. 269: 544, 1963. CrossrefMedlineGoogle Scholar102. BOWERMASON BFDM: Measurement of antidiuretic activity (ADA) in plasma and tumor in carcinoma of the lung with inappropriate antidiuresis. Clin. Res. 12: 121, 1964. Google Scholar103. PEARTPORTERROBERTSONSANDLERBOLDOCK WSKAJIME: Carcinoid syndrome due to pancreatic-duct neoplasm secreting 5-hydroxytryptophan and 5-hydroxytryptamine. Lancet 1: 239, 1963. CrossrefMedlineGoogle Scholar104. HUNGBLIZZARDMIGEONCAMACHONYHAN WRMCJAMWL: Precocious puberty in a boy with hepatoma and circulating gonadotropin. J. Pediat. 63: 895, 1963. CrossrefMedlineGoogle Scholar105. MCARTHUR JW: Para-endocrine phenomena in obstetrics and gynecology, in Progress in Gynecology, Vol. IV, edited by MEIGS, J. V., STURGIS, S. H., Grune & Stratton, New York, 1963. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MORTIMER B. LIPSETT, M.D., F.A.C.P.; WILLIAM D. ODELL, M.D.; LEON E. ROSENBERG, M.D.; THOMAS A. WALDMANN, M.D.Affiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Mortimer B. 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M.D., F.A.C.P., THOMAS M.D., M.D., M.D., M.D., WILLIAM ODELL, M.D., F.A.C.P., ROSS, M.D., F.A.C.P., L. M.D., F.A.C.P., M.D., F.A.C.P., M.D., hormone in patients with carcinoma of the hypercalcemia and without metastases CASE OF of Carcinoma and pleural mesothelioma associated with hypoglycemia and of various endocrine by associated with of human factor in malignant of A and of the the Actions of of the Adrenal in und Syndromes Associated with of of hepatic and of tissue AND tumor of the breast with bone by and syndromes associated with tumors of the and and in a M.D., S. M.D., M.D., M.D., F.A.C.P., S. M.D., M.D., M.D., OF and Primary L. M.D., I. M.D., and on in Patients with A in hormone in lung cancer and — The Syndromes Associated with Nonendocrine Syndromes of carcinoma simulating on the mechanism of hypoglycemia in a with massive and of endocrine syndromes associated with of non-endocrine Renal Carcinoma Associated with Hypercalcemia and Metabolic S. J. M.D., B. associated with Production of and by a Tumor 1 October and 1 1 October PDF
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