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Isolation of deoxyribonucleate from a concentrated solution of thymonucleoprotein has been achieved by disruption of the protein nucleate bond with potassium thiocyanate, adsorption of the protein on celite, and alcohol precipitation of the deoxyribonucleate from aqueous salt solution. Highly polymerized nucleate can be obtained readily from 1 lb of calf thymus tissue in high yield.
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R. O. Hurst (1958) studied this question.
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