This report documents the occurrence of hemolytic-uremic syndrome in siblings, highlighting variable clinical outcomes from complete recovery to fatal uremia.
Answers are grounded in this paper and cite their sources.
Variable sibling hemolytic-uremic syndrome outcomes caution prognostic assumptions; leaves open genetic or environmental modifiers.
RECENT reviews1 , 3 do not mention the hemolytic-uremic syndrome of children in siblings except for the fatal outcome in six-month-old, hyperlipemic monozygotic twins.3 We encountered this syndrome in siblings. One died of uremia after repeated episodes. The other recovered completely after one episode.Case 1. An 8-month-old girl seen in June. 1949. had had fever and dark urine for 2 days. Physical examination showed only fever. Laboratory findings included anemia. increased blood urea. proteinuria and erythrocyturia. A blood smear disclosed anisocytosis poikilocytosis and burr cells. She subsequently had similar episodes and died of azotemia, hypertension and anuria in 1957. Histologic find . . .
No takes yet. Share an insight, caveat, or question.
Hagge et al. (1967) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: