What question did this study set out to answer?

To evaluate corticotropic activity in human blood and review the reliability and reproducibility of current clinical assay methods across healthy individuals and endocrine disorders.

June 1, 1954The Journal of Clinical Endocrinology & Metabolism

Corticotropic Activity of Human Blood*

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Authors

JPJAIME PARISMayo Clinic MUMARK UPSONMayo Clinic RSRandall G. SpragueShady Grove Fertility Center

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Implication

Laboratory assay evaluation demonstrates detectable corticotropin in untreated Addison disease but not normal serum, highlighting inconsistencies in clinical hormone measurement.

Key Points

To evaluate corticotropic activity in human blood and review the reliability and reproducibility of current clinical assay methods across healthy individuals and endocrine disorders.
Assayed corticotropic activity in blood and urine samples from healthy individuals and patients diagnosed with untreated Addison's disease or Cushing's syndrome.
Reviewed and synthesized experimental assay data alongside conflicting published findings on blood corticotropin levels in normal and pathological conditions.
Corticotropin was consistently detected in the serum of patients with untreated Addison's disease.
Corticotropic activity was not consistently detectable in the serum or urine of healthy persons or patients with Cushing's syndrome.

Cite This Study

PARIS et al. (1954) studied this question.

synapsesocial.com/papers/6a870e2cc026610cc182cd85 https://doi.org/10.1210/jcem-14-6-597

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Implication

Laboratory assay evaluation demonstrates detectable corticotropin in untreated Addison disease but not normal serum, highlighting inconsistencies in clinical hormone measurement.

Corticotropic Activity of Human Blood*

Discussion

Member takes

Implication

Key Points

Cite This Study

Corticotropic Activity of Human Blood*

Discussion

Member takes

Implication

Key Points

Cite This Study

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