The Syndrome of Intrathoracic Neoplasia With Bilateral Hyperfunction of the Adrenal Cortex

Editorials1 June 1961THE SYNDROME OF INTRATHORACIC NEOPLASIA WITH BILATERAL HYPERFUNCTION OF THE ADRENAL CORTEXA. GORMAN HILLS, M.D., KENNETH A. WOEBER, M.B., Ch.B.A. GORMAN HILLS, M.D.Search for more papers by this author, KENNETH A. WOEBER, M.B., Ch.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this issue1, 2 are reported two further instances of a striking and as yet imperfectly understood association between intrathoracic neoplasms and adrenal cortical hyperplasia and hyperfunction. Such an association, occasionally noticed from time to time in the past, is now being recorded with such frequency as to leave no doubt that the coexistence of these two disease processes is more than fortuitous. It is time to take stock of this syndrome both in the interest of the diagnostician and because of its intrinsic interest from the standpoint of pathophysiology.To date 30 case reports1-11have appeared in the...1 EscovitzReingold WEIM: Functioning malignant bronchial carcinoid with Cushing's syndrome and recurrent sinus arrest. Ann. Intern. Med. 54: 1248, 1961. LinkGoogle Scholar2 MarksAndersonLiberman LJAEH: Carcinoma of lung associated with marked adrenocortical hyperplasia and adrenal hyperresponsiveness to ACTH in the absence of Cushing's syndrome. Ann. Intern. Med. 54: 1243, 1961. LinkGoogle Scholar3 AllottSkelton ENMO: Increased adrenocortical activity associated with malignant disease. Lancet 2: 278-83 (Aug.) 1960. CrossrefMedlineGoogle Scholar4 Bagshawe KD: Hypokalaemia, carcinoma and Cushing's syndrome. Lancet 2: 284-87 (Aug.) 1960. CrossrefMedlineGoogle Scholar5 Christy NP: Adrenocorticotrophic activity in the plasma of patients with Cushing's syndrome associated with pulmonary neoplasms. Lancet 1: 85-86 (Jan.) 1961. CrossrefMedlineGoogle Scholar6 BornsteinNolanBernanke PJPD: Adrenocortical hyperfunction in association with anaplastic carcinoma of the respiratory tract. New Engl. J. Med. 264: 363-71 (Feb.) 1961. CrossrefGoogle Scholar7 HarrisonMontgomeryRamseyRobertsonWelbourn MTDAASJHRB: Cushing's syndrome with carcinoma of bronchus and with features suggesting carcinoid tumor. Lancet 1: 23-25 (Jan.) 1957. CrossrefGoogle Scholar8 Rosenthal FD: Adrenocortical hyperactivity in a patient with bronchial carcinoma and diabetes mellitus. Brit. Med. J. 2: 139-41 (July) 1957. CrossrefMedlineGoogle Scholar9 GoldSchnider GLBI: Some unusual syndromes associated with neoplastic disease. Ann. Intern. Med. 51: 890-96 (Nov.) 1959. LinkGoogle Scholar10 CohenTollCastleman RBGDB: Bronchial adenomas in Cushing's syndrome: their relation to thymomas and oat cell carcinomas associated with hyperadrenocorticism. Cancer 13: 812-17 (July-Aug.) 1960. CrossrefMedlineGoogle Scholar11 MetzlerFlink CEB: Adrenal cortical hyperfunction associated with metastatic bronchogenic carcinoma. J. Lancet 76: 242-44 (Aug.) 1960. Google Scholar12 ScholzBahn DARC: Thymic tumors associated with Cushing's syndrome: review of three cases. Proc. Mayo Clinic. 34: 433-41 (Sept.) 1959. MedlineGoogle Scholar13 Lockwood CH: Studies of adrenal cortical function in three cases of carcinoma. Canad. Med. Ass. J. 79: 728-35 (Nov.) 1958. MedlineGoogle Scholar14 SpraguePowerMasonAlbertMathiesonHenchKendallSlocumbPolley RGMHHLADRPSECCHHF: Observations on the physiologic effects of cortisone and ACTH in man. Arch. Intern. Med. 85: 199-258 (Feb.) 1950. CrossrefGoogle Scholar15 Liddle WG: Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J. Clin. Endocr. 20: 1539-60 (Dec.) 1960. CrossrefMedlineGoogle Scholar16 MoerschMcDonald HJJR: The significance of cell types in bronchogenic carcinoma. Dis. Chest 23: 621-33 (June) 1953. CrossrefMedlineGoogle Scholar17 LiddleIslandRinfretForsham GWDPAPPH: Factors enhancing the response of the human adrenal to corticotropin: is there an adrenal growth factor? J. Clin. Endocr. 14: 839-58 (Aug.) 1954. CrossrefGoogle Scholar18 JailerLongsonChristy JWDNP: Studies in Cushing's syndrome. II. Adrenal weight-maintaining activity in the plasma of patients with Cushing's syndrome. J. Clin. Invest. 36: 1608-14 (Nov.) 1957. CrossrefMedlineGoogle Scholar19 NugentEik-NesKentSamuelsTyler CAKHSLTFH: A possible explanation for Cushing's syndrome associated with adrenal hyperplasia. J. Clin. Endocr. 20: 1259-68 (Sept.) 1960. CrossrefGoogle Scholar20 WilliamsOldfieldIslandLiddle WCRADPGW: Blood ACTH in Cushing's disease. J. Clin. Invest. 39: 1040, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Section of Endocrinology and Metabolism, Department of Medicine, University of Miami School of Medicine, Coral Gables, Fla.Requests for reprints should be addressed to Dr. Hills at Jackson Memorial Hospital, Miami 36, Fla. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnhancement of lymphocyte production by adrenocortical inhibitionUltrastructural studies of an acth-secreting thymic tumorSteroid hormone abnormalities in patients with carcinoma of the lungCushing's Syndrome and the HypophysisA review of unusual systemic manifestations associated with carcinomaROENTGENOGRAM OF THE MONTHElectrolyte disturbances associated with cancerFurther studies of adrenocortical function in patients with carcinoma of the lungBronchogenic carcinoma and peptic ulcer 1 June 1961Volume 54, Issue 6Page: 1295-1300KeywordsAdrenal cortexEndocrinology ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...