Inhibition of Corticosteroid Secretion by Amphenone in a Patient with Adrenocortical Carcinoma

AMPHENONE was synthesized in 1950 by Allen and Corwin1 as one of a series of substituted desoxybenzoins and was selected by Hertz and his collaborators2 , 3 as a compound of potential biologic interest because of its structural relation to synthetic estrogens. These investigators found that the substance exerted progestational activity in the rabbit, and a partly progestational, partly estrogenic activity in the rat. In addition, amphenone was shown to produce enlargement of both the adrenal and the thyroid glands. Later studies concerned primarily the nature of the adrenal enlargement and it was suggested that amphenone interfered with the production of active . . .