Key result
Surgical trauma from an open biopsy likely contributed to the development of metastatic osteosarcoma at a remote contralateral site in a patient with proximal humerus osteosarcoma.
Case Report (n=1)
Surgical trauma from a biopsy may contribute to the development of unusual metastasis in osteosarcoma, suggesting biopsy and definitive resection should be done on separate occasions.
May indicate biopsy-related metastasis risk in osteosarcoma; hypothesis-generating and should not change practice without further evidence.
In a patient who presented with an osteosarcoma of the proximal humerus, systemic staging revealed a lesion in the contralateral humerus, which was shown to be an enchondroma after open biopsy. The patient had a local recurrence develop, which necessitated forequarter amputation. Shortly thereafter, the patient had pain develop at the contralateral biopsy site, and examinations and repeat biopsy revealed metastatic osteosarcoma. We think it is likely that surgical trauma contributed to the development of this unusual metastasis. In this clinical situation, consideration should be given to doing the biopsy and definitive resection on separate occasions.
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Ferguson et al. (2004) conducted a case report in Osteosarcoma (n=1). Open biopsy (surgical trauma) was evaluated on Metastasis at remote biopsy site. Surgical trauma from an open biopsy likely contributed to the development of metastatic osteosarcoma at a remote contralateral site in a patient with proximal humerus osteosarcoma.
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