In the course of our search for new antibiotics, a strain of Bacillus circulans No. YQW-B6 was isolated from a soil sample collected in Taiwan. This organism produced a complex of aminoglycoside antibiotics designated Bu-1709, and the two major components, A1 and A2, were identified as butirosins A (I) and B (II)2-4), respectively. This paper reports the bioactive degradation products from butirosins and the semi-synthesis of butirosin analogs.
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TSUKIURA et al. (1973) studied this question.
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