Animal experiment demonstrates joint sarcoma induction following DMBA injection in rats, indicating tumors originate from synovium and subsynovial tissues.
Sarcomas were produced in and around the knee joint of rats by the injection of DMBA into the joint cavity. A study of the early changes that occur in the synovium and the continuity of the established tumor with this tissue strongly suggests that the experimental procedure employed produced tumors from the synovium and the superficial layers of the subsynovial tissues. Convincing histological evidence of synovial differentiation was seen only in six cases. Eleven other tumors were considered to be either fibrosarcomas or anaplastic sarcomas of synovial origin.
No takes yet. Share an insight, caveat, or question.
Ghadially et al. (1966) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: