Key result
Caveolin plays a crucial role in cardiovascular diseases by regulating endothelial function, lipid homeostasis, and cardiac function, and its crosstalk with autophagy represents a novel therapeutic target.
Caveolin is a key structural protein that regulates endothelial function and lipid homeostasis, making it a potential therapeutic target for various cardiac and vascular diseases.
Caveolin modulation may identify new targets in endothelial and cardiac disease; leaves open clinical translation pending targeted trials.
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
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Tian et al. (2020) conducted a review in Cardiac and Vascular Diseases. Caveolin targeted therapies was evaluated. Caveolin plays a crucial role in cardiovascular diseases by regulating endothelial function, lipid homeostasis, and cardiac function, and its crosstalk with autophagy represents a novel therapeutic target.
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