After a eleven-steps purification, a peptidyl factor named α substance-IA was isolated in pure form from a culture filtrate of α type cells of the heterothallic Saccharomyces cerevisiae. The substance induced the sexual agglutinability in a haploid cells belonging to the opposite mating type at concentrations from 0.4 to 0.8 ng/ml.
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Sakurai et al. (1977) studied this question.
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