Key result
A 48-year-old woman with primary splenic angiosarcoma achieved long-term, disease-free survival of approximately 5 years following splenectomy, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.
Case Report (n=1)
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High-dose chemotherapy with autologous peripheral blood stem cell transplantation after splenectomy may provide long-term disease-free survival in patients with primary splenic angiosarcoma.
A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.
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Hara et al. (2010) conducted a case report in Primary splenic angiosarcoma (n=1). Splenectomy, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation was evaluated on Survival. A 48-year-old woman with primary splenic angiosarcoma achieved long-term, disease-free survival of approximately 5 years following splenectomy, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.
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