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December 1, 1975Proceedings of the National Academy of SciencesOpen Access

Specific human B lymphocyte alloantigens linked to HL-A.

Dean L. Mann Leslie D. Abelson Pierre A. Henkart Susanna Harris D. Bernard Amos

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Abstract

Sera, previously found to react specifically with B lymphoid cultured cells, were tested on isolated T and B peripheral blood lymphocytes in a microcytotoxicity assay. Studies were performed on lymphocytes obtained from several large Amish families. The sera used in these studies were cytotoxic to peripheral blood, B lymphocytes, but not cytotoxic to T lymphocytes. The antigens detected followed the inheritance pattern of HL-A haplotypes. The strong linkage disequilibrium with HL-A antigens suggests that genes controlling the expression of B lymphocyte antigens are linked to genes controlling HL-A alloantigens.

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Mann et al. (1975) studied this question.

synapsesocial.com/papers/6a8718fa48ef9afcd2a25f1c https://doi.org/10.1073/pnas.72.12.5103

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