Answers are grounded in this paper and cite their sources.
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
No takes yet. Share an insight, caveat, or question.
Tian et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: