What is the clinical evidence from this study?

Study design: Editorial. Population: Venous and arterial thrombosis.

What does this research mean for the field?

Venous and arterial thrombosis represent a continuous pathophysiological spectrum linked centrally by endothelial dysfunction and shared inflammatory and vascular risk factors. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine whether venous and arterial thrombosis share common endothelial, inflammatory, and cellular mechanisms, representing a continuous biological spectrum rather than distinct disorders.

August 20, 2026European Heart Journal

Venous and arterial thrombosis: a continuous spectrum of the same disease?

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Key result

This editorial discusses the continuous spectrum of venous and arterial thrombosis, emphasizing endothelial dysfunction as a central mechanism linking both conditions.

Design

Editorial

Authors

CJCarlos Jerjes‐SánchezVascular / Pulmonary Vascular

Discussion

Member takes

Implication

This editorial emphasizes the growing evidence that venous and arterial thrombosis may represent a continuous spectrum of disease driven by endothelial dysfunction and shared risk factors.

Key Points

To examine whether venous and arterial thrombosis share common endothelial, inflammatory, and cellular mechanisms, representing a continuous biological spectrum rather than distinct disorders.
Synthesized clinical trials and epidemiological cohorts evaluating vascular pathology, including meta-analyses of antiplatelet therapies in deep vein thrombosis and pulmonary embolism (N=87,891).
Assessed carotid ultrasonography data comparing atherothrombotic plaque prevalence among patients with spontaneous versus secondary deep vein thrombosis.
Reviewed prospective 3-year outcomes measuring cardiovascular events and mortality following acute pulmonary embolism.
Antiplatelet therapy lowered deep vein thrombosis incidence from 34% in controls to 25% and reduced fatal pulmonary embolism by 58% across 87,891 evaluated patients.
Carotid plaques occurred in 47% (95% CI, 39–50%) of patients with spontaneous deep vein thrombosis compared to 32% (95% CI, 25–39%) of control participants.
Patients recovering from acute idiopathic pulmonary embolism experienced high 3-year incidence rates of both recurrent venous thromboembolism and adverse arterial cardiovascular events.

PICO

Population

Venous and arterial thrombosis

This editorial emphasizes the growing evidence that venous and arterial thrombosis may represent a continuous spectrum of disease driven by endothelial dysfunction and shared risk factors.

Cite This Study

Carlos Jerjes‐Sánchez (2004) conducted an editorial in Venous and arterial thrombosis. This editorial discusses the continuous spectrum of venous and arterial thrombosis, emphasizing endothelial dysfunction as a central mechanism linking both conditions.

synapsesocial.com/papers/6a871afb0d8e255da0bc298e https://doi.org/10.1093/eurheartj/ehi041

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Implication

This editorial emphasizes the growing evidence that venous and arterial thrombosis may represent a continuous spectrum of disease driven by endothelial dysfunction and shared risk factors.

Venous and arterial thrombosis: a continuous spectrum of the same disease?

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Venous and arterial thrombosis: a continuous spectrum of the same disease?

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Also Consider

Also Consider