Cell-permeable, biocompatible nanoparticles consisting of a positively charged polymer, which is conjugated to a near-infrared (NIR) fluorochrome and a protein-kinase-specific peptide, and a negatively charged polymer constitute innovative probes for measuring protein kinase activity in living cells. Protein kinase activity selectively induces dissolution of the nanoparticles and is accompanied by a strong NIR fluorescence signal (see scheme).
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Bernhard Schuster (2007) studied this question.
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