A selective and sensitive turn-on fluorescent NIR probe for cysteine has been developed. Cleavage of 2,4-dinitrobenzenesulfonyl (DNBS) with thiols switches the weakly fluorescent aza-BODIPY dye (λ(em) = 734 nm, Φ(f) = 0.03) to a strongly fluorescent species in the NIR region (λ(em) = 755 nm, Φ(f) = 0.14).
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Jiang et al. (2012) studied this question.
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