Let it go: Virus-like particles (VLPs) incorporating a peptide-tag were constructed. Fluorescent dye molecules attached to nitrilotriacetic acid (NTA) were encapsulated within the VLPs as model drug molecules by using the affinity between a hexahistidine motif (His6) and NTA. The model drug molecules were released under acidic conditions due to the protonation of histidines.
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Ohtake et al. (2010) studied this question.
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