An ultrastructural study of a postirradiation pseudosarcoma of the skin is reported and compared to the spindle cell variant of squamous carcinoma in order to exclude epithelial histogenesis of the former. The pseudosarcoma tissue was composed of cells having the ultrastructural features characteristic of myofibroblasts. The cells of the spindle cell variant of the squamous carcinoma demonstrated the presence of tonofibrils which were joined by many desmosomes. These findings contradict the concept of an epithelial origin of the spindle-shaped cells of pseudosarcoma.
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Woyke et al. (1974) studied this question.
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