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Several investigations reported modulation of lymphocyte functions following activation of the histamine H₂ receptor. However, few data have accumulated with regard to the distribution of histamine H₂ receptors on different lymphocyte subsets. Conversely, the distribution of histamine H₁ receptors on different lymphocyte subsets has been thoroughly analyzed using specific radioligands, whereas the functional significance of histamine H₁ receptor ligation on lymphocytes has not been fully elucidated yet. Recent investigations suggest that H₁R signaling on lymphocytes may enhance whereas activation of the H₂R may inhibit lymphocyte responses. In this review, the authors discuss the current knowledge on distribution and functional significance of histamine H₁ and histamine H₂ receptors on human lymphocytes.
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Sachs et al. (2000) studied this question.
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