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Isolation of 2R,5R -dihydroxymethyl-3R,4R –dihydroxypyrrolidine (DMDP, 1) was isolated from the fermentation broth of Streptomyces sp. KSC-5791 by chromatographic techniques including preparative HPLC in a Shodex Asahipak NH2P-50 column. Compound 1 inhibited trehalases of Corynebacterium sp. 1) and diamondback moth (Plutella xylostella), but did not inhibit porcine kidney trehalase.
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Watanabe et al. (1995) studied this question.
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