Why the study?
The prognostic significance of the p53 gene polymorphism (Arg72Pro exon 4, rs1042522) on developing cardiotoxic left ventricular remodeling and heart failure was unclear.
Does p53 gene polymorphism (Arg72Pro) predict the development of anthracycline-induced cardiotoxicity in women with breast cancer?
Does p53 gene polymorphism (Arg72Pro) predict the development of anthracycline-induced cardiotoxicity in women with breast cancer?
The p53 Arg72Pro polymorphism (Arg/Arg genotype) is a significant genetic predictor of anthracycline-induced cardiotoxicity in breast cancer patients, potentially allowing for early risk stratification.
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Arg72Pro polymorphism may flag higher cardiotoxicity risk after anthracyclines; leaves open need for prospective validation before genotyping informs surveillance.
Шилов et al. (2019) studied this question.
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