Cocaine abuse leads to multifactorial cardiotoxic mechanisms, including myocardial infarction, which can present simultaneously in a single patient.
Multifactorial mechanisms warrant broad evaluation in cocaine-associated MI; leaves open dominant pathway targeting for future therapies.
The underlying mechanisms of myocardial infarction as a result of cocaine abuse appear to be multifactorial. The various cardiotoxic mechanisms and interrelationships of cocaine are fully reviewed, and a chart has been reconstructed to give the reader a clearer understanding of them. Moreover, an unusual case of a 29-year-old male cocaine abuser is presented because it illustrates many of the reported cardiotoxic effects, all of which are present in the same individual.
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Zugibe et al. (1998) studied this question.
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