This case report describes a rare presentation of myocardial infarction in two young sisters caused by advanced intimal fibrous proliferation rather than typical atherosclerotic changes.
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May prompt consideration of nonatherosclerotic coronary disease in young familial MI; leaves open genetic mechanisms of isolated intimal fibrous proliferation.
Myocardial infarction occurred in two sisters, ages 18 and 19 years, respectively. The younger (case 1) died following an attempt to revascularize the myocardium by the Vineberg procedure. The lesions in this case differed from the arteriosclerotic changes usually present in occlusive coronary artery disease in that an advanced degree of intimal fibrous proliferation without associated lipid or calcium deposits was the sole pathological process observed.
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I. C. BRILL (1971) studied this question.
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