Why the study?
Does dipyridamole stimulate prostacyclin biosynthesis in animal tissue models?
Does dipyridamole stimulate prostacyclin biosynthesis in animal tissue models?
Dipyridamole stimulates the second step of prostacyclin biosynthesis, providing a potential mechanistic basis for its therapeutic use in myocardial infarction.
May support mechanistic role in MI; animal data leave human translation unresolved.
1 Dipyridamole (0.01 to 0.75 mM) increased prostacyclin (PGI2) biosynthesis from tritiated arachidonic acid in rat stomach fundus homogenates by 21 to 350%. The transformation of prostaglandin H2 (PGH2) to PGI2 by a microsomal fraction of pig aorta was stimulated by dipyridamole at 0.1 M by 63%. 2 In the isolated perfused heart of the rabbit dipyridamole at 1 and 5 micrograms/ml increased PGI2 release by 70% and 146% respectively. 3 Our results show a stimulation of the second step in PGI2 biosynthesis (from endoperoxides) by dipyridamole. This effect should be considered in relation to the therapeutic usage of the drug in myocardial infarction.
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BLASS et al. (1980) studied this question.
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