The Association of Hyperuricemia with Glaucoma: A Nationwide Cross-Sectional Study from the Republic of Korea

Purpose: We assessed the association between hyperuricemia and glaucoma.Methods: A population-based, cross-sectional analysis was performed using Korean National Health and Nutrition Examination Surveys spanning from 2019 to 2021.A total of 10,074 subjects ≥ 19 years of age were analyzed.Hyperuricemia was defined as a serum uric acid level ≥ 7 mg/dL in male and ≥ 6 mg/dL in female.Results: Hyperuricemia participants were associated with a significantly higher odds ratio (OR) of glaucoma than control group in univariable (OR, 1.51; 95% confidence interval [CI], 1.15-2.00)and multivariable analysis (OR, 1.46; 95% CI, 1.09-1.96).Glaucoma was also significantly associated with hyperuricemia in male subgroup after adjusting for confounding variables (OR, 1.53; 95% CI, 1.07-2.19),whereas no significant association was observed in the female group.Conclusions: Our study suggested that individuals with hyperuricemia exhibit elevated risk of glaucoma in comparison to the control group.Further prospective investigations are required to ascertain the potential link between elevated uric acid levels and the development of glaucoma.