Photosensitivity Due to Chlorothiazide and Hydrochlorothiazide

CHLOROTHIAZIDE and hydrochlorothiazide are aromatic sulfonamides differing from each other only in that in the hydrochlorothiazide the 3, 4 carbon-nitrogen bond is saturated by 2 hydrogen atoms whereas in the chlorothiazide molecule it remains dehydrogenated. The reported cases of cutaneous eruptions after chlorothiazide to date have been few,1 2 3 4 5 including 2 cases of photodermatitis.6 , 7 No eruptions due to hydrochlorothiazide have been reported. In addition to various eruptions due to these drugs we have studied 4 cases associated with photosensitization.Case Histories¶Case 1. Mrs. A.A., a 61-year-old obese woman, who was under treatment for hypertensive cardiovascular disease and was receiving hydrochlorothiazide, . . .