Why the study?
Appropriate treatment options for soft tissue sarcoma patients with brain metastasis needed to be ascertained by evaluating the association of clinical characteristics with treatment outcomes.
Does combined surgery and postoperative radiotherapy improve survival in soft tissue sarcoma patients with brain metastasis?
Does combined surgery and postoperative radiotherapy improve survival in soft tissue sarcoma patients with brain metastasis?
Combined surgery and postoperative radiotherapy may prolong survival in the rare subset of soft tissue sarcoma patients who develop brain metastasis.
BACKGROUND/AIM: This study aimed to evaluate the association of clinical characteristics with treatment outcomes to ascertain the appropriate treatment options for soft tissue sarcomas (STS) patients with brain metastasis (BM). PATIENTS AND METHODS: Medical records of STS patients with BM who were treated in our institutions were retrospectively reviewed, and analyzed to identify the factors associated with post-BM survival. RESULTS: Among the 509 STS patients, BM occurred in five patients (0.98%). The median survival after BM was 1.5 months. Histological subtypes of the primary lesions in the five BM patients were: two synovial sarcomas, one myxoid liposarcoma, one alveolar soft part sarcoma, and one rhabdomyosarcoma. Among the five BM patients, the post-BM survival of two patients, who underwent surgery and postoperative radiotherapy, was longer than that of the other patients (p<0.01). CONCLUSION: Combined surgery and postoperative radiotherapy effectively managed symptoms and prolonged survival in STS patients with BM.
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Takemori et al. (2021) studied this question.
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