Why the study?
Does the mTNF/TNFR ratio correlate with the development of multiple organ dysfunction syndrome in trauma patients?
Does the mTNF/TNFR ratio correlate with the development of multiple organ dysfunction syndrome in trauma patients?
A dual deregulation in monocyte TNF-alpha production, reflected by an increased mTNF/TNFR ratio, correlates with the development of multiple organ dysfunction syndrome in trauma patients.
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May identify trauma patients at risk for organ failure; hypothesis-generating and requires prospective validation before clinical use.
Pellegrini et al. (1996) studied this question.
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