An automated radioimmunoassay for methotrexate using an iodinated tracer has been applied to the centrifugal analyser, Centria System 2. Results obtained for serum samples correlated closely with those using a manual radioimmunoassay method. A major advantage of the assay is its potential for processing large numbers of samples rapidly, making it highly suitable for routine clinical use.
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Quinton et al. (1980) studied this question.
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