Necropsy measurements of cerebral ventricular volume and pericerebral space in senile dementia patients and age-matched controls indicate that ventricular enlargement is not an accurate diagnostic marker for cerebral atrophy. Furthermore, ventricles are of normal size for age in about 40% of all senile dementia patients including those with Alzheimer's disease.
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Hubbard et al. (1981) studied this question.
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