Sirolimus-Induced Interstitial Pneumonitis in an Islet Transplant Recipient

T ype 1 diabetes is associated with other autoimmune diseases. Many diabetes centers routinely screen patients with type 1 diabetes for autoimmune thyroid disease (ATD). The presence of two autoimmune diseases raises the possibility of polyendocrine autoimmune disease. The association of autoimmune adrenal insufficiency, or Addison's disease, with type 1 diabetes is described in case reports dating back more than a century (1,2). Studies have i l l u s t r a t e d s h a r e d H L A a l l e l e s (DQA1*0501, for example) among patients with type 1 diabetes, ATD, and Addison's disease (3,4). Pancreatic islet cell antibodies have been detected in 6.2% of patients with Addison's disease ( Yet, it is unclear whether patients with type 1 diabetes should be routinely screened for Addison's disease.