, respectively. Based on the small halide dependence, we interpreted the C[double bond, length as m-dash]O group of the Q107 side chain as the hydrogen-bonding acceptor. Moreover, the anion stabilized the protonated state without a direct hydrogen bond with the Schiff base. Structures around the Schiff base region are discussed for the WT and E107 mutants of HeR 48C12.
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Singh et al. (2019) studied this question.
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