See and treat: An amphiphilic bisporphyrin and its YbIII complex Yb⋅1 are characterized by an appropriate hydrophobicity/hydrophilicity balance for membrane transport. Their cellular uptake by a rat tumor-cell model is ten times higher than that of the parent tetracationic porphyrin, and their activity as photodynamic therapeutics is correspondingly stronger. The near-IR-luminescence of Yb⋅1 is potentially useful for tumor imaging.
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Jiang et al. (2008) studied this question.
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