October 6, 1978Science

Impulse Blockade in Frog Cardiac Ganglion Does Not Resemble Partial Denervation in Changing Synaptic Organization

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Structured PICO

Population

Frog heart parasympathetic neurons (cardiac ganglion)

Intervention

Blockage of impulses in one vagus nerve with tetrodotoxin-impregnated cuffs

Comparator

Partial denervation by surgical section of one vagus nerve

Outcome

Reorganization of functional synaptic connections in the ganglionsurrogate

Synaptic reorganization following partial denervation in the frog cardiac ganglion is not solely due to a lack of impulse activity.

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Challenges activity-only models of autonomic synaptic reorganization; leaves open non-activity mechanisms for mammalian study.

Roper et al. (1978) studied this question.

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