Following a brief introduction to properties of the red blood cell (RBC), this review will provide information pertaining to the role of the RBC as both a deliverer of nitric oxide (NO), and a stimulator of NO release via RBCgenerated ATP. In addition, an evaluation of the potential downstream effects of RBC-derived ATP, via its ability to stimulate NO in other cell types, will be provided. Collectively, it is now apparent that the RBC is a determinant in functions other than oxygen delivery alone.
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Stephen T. Halpin (2011) studied this question.
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