Synthese eines 33gliedrigen Polyaminolactams durch Anwendung der «zip»‐Reaktion. 6. Mitteilung über Umamidierungsreaktionen

Synthesis of a 33‐membered Polyaminolactam by Use of the Zip‐reaction The pentaamino lactam derivative 11 was synthesized from the 13‐membered tosylaminolactam 2 . The prolongation of the side chain was achieved using the phthalimido derivative 3 . After removal of the protecting groups the resulting base 11 was treated with KAPA reagent (1,3‐propanediamine/potassium‐3‐aminopropyl‐amid). By zip‐reaction the 33‐membered 13, 17, 21, 25, 29‐pentaaza‐32‐dotriacontanelactam ( 1 ) was formed in 85% yield.