Describes a novel chemical synthesis method for substituted azetidin-3-ones using an intramolecular ring-closure reaction.
New synthetic route to azetidin-3-ones; leaves open medicinal chemistry applications pending further validation.
Tri-n-butyltin hydride–azoisobutyronitrile-mediated intramolecular ring-closure reactions yield 2-cyano-1,2-di(phenyl or substituted phenyl)azetidin-3-ones; 15 N NMR studies support the assigned structures.
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Chowdhury et al. (1997) studied this question.
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