Synthese von N‐(4‐Aminobutyl)‐16‐aza‐19‐nonadecanlactam und N‐(4‐Aminobutyl)‐17‐aza‐20‐icosanlactam (Desoxoinandenin)

Synthesis of N ‐(4‐Aminobutyl)‐16‐aza‐19‐nonadecanelactam and N ‐(4‐Aminobutyl)‐17‐aza‐20‐icosanelactam (Desoxoinandenine) According to Scheme 1 , the two homologous macrocyclic spermidine derivatives 12 and 23 were synthesized. Key steps in both cases were two different types of ring‐enlargement reactions. Compound 12 was identical with a degradation product of the naturally occurring spermidine alkaloids of inandenine‐type.