Why the study?
Does varying the duty factor of ultrasound-mediated cardiac stimulation affect heart rate in rats?
Does varying the duty factor of ultrasound-mediated cardiac stimulation affect heart rate in rats?
Ultrasound-mediated cardiac stimulation demonstrates a possible duty factor threshold for cardiac pacing, with heart rate decreases observed at 0.50% and 1.00% DF but not at 0.25% DF in rats.
Supports duty factor threshold for ultrasound cardiac effects in rats; hypothesis-generating and should not yet change practice.
The role of the duty factor (DF) in ultrasound-mediated cardiac stimulation is studied. Five 3-month-old female rats were exposed transthoracically to 3.5-MHz ultrasonic pulses of 2.0-MPa peak rarefactional pressure amplitude, variable DF, and variable pulse repetition frequency. A change in the heart rate was not observed following the 0.25%-DF sequence. A decrease of ∼4% in the heart rate was observed following the 0.50%-DF and 1.00%-DF sequences. Outcomes suggest a possible DF threshold for cardiac pacing.
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Coiado et al. (2014) studied this question.
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