A chromosome survey was made in the following human malignant tumors in vivo; sixteen gastric cancers, five maxillary cancers, four laryngeal cancers, two penis cancers and four reticulosarcomas.Evidence was presented that in each tumor stem-cells are present with a characteristic range and mode of chromosome numbers and a particular idiogram by which the tumor is clearly distinguishable from other tumors, as well as from the ordinary tissue. The stemline chromosome numbers show a wide variation ranging from hypodiploid to hypertetraploid.It was shown that most of the chromosomes of neoplastic cells differ in shape and/or size from those of normal cells; it is assumed that in tumor chromosomes considerable structural and mutational changes must have occurred probably correlated with the neoplastic condition.
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Toshihide Tabata (1959) studied this question.