False-Positive Anti-HCV in Biliary Cirrhosis

Letters1 February 1991False-Positive Anti-HCV in Biliary CirrhosisChantal Housset, Claire Hirschauer, Françoise DegosChantal HoussetSearch for more papers by this author, Claire HirschauerSearch for more papers by this author, Françoise DegosSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-252_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:A high prevalence of anti-hepatitis C virus (HCV) antibodies detected by enzyme immunoassay (HCV-EIA, Ortho) (1) has been reported in patients with various liver diseases, particularly in those with auto-immune chronic liver disease (2). We used a recombinant-based immunoblot assay (RIBA, Chiron-Ortho) (3) to investigate the specificity of the HCV-EIA in 90 patients with histologically proven primary biliary cirrhosis. Liver histologic stages according to Scheuer (4) were 1-2, 3, and 4 in 25, 22, and 43 patients, respectively. Serum samples were stored at -20 °C until tested, for less than 2 months and for 2 to 48...References1. KuoChooAlter GQH. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989;244:362-4. CrossrefMedlineGoogle Scholar2. McFarlaneSmithJohnsonBrayVerganiWilliams IHPGDR. Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result? Lancet. 1990;335:754-7. CrossrefMedlineGoogle Scholar3. ColomboRumiMannucci MMP. Specificity of hepatitis C antibody ELISA in patients with haemophilia. Lancet. 1990:335: 1345. CrossrefMedlineGoogle Scholar4. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 1967;60:1257-60. MedlineGoogle Scholar5. Sanchez-TapiasBarreraCosta JJJ. Hepatitis C virus infection in patients with nonalcoholic chronic liver disease. Ann Intern Med. 1990;112:921-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Beaujon 92110 Clichy France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis C virus in autoimmune liver disease in the UK: aetiological agent or artefact?Low prevalences of HBV and HCV infection in patients with primary biliary cirrhosis in Taiwan: A case control study 1 February 1991Volume 114, Issue 3Page: 252-252KeywordsAntibodiesChronic liver diseaseCirrhosisEnzyme immunoassayLiverLiver diseasesPrimary biliary cirrhosisSpecificity Issue Published: 1 February 1991 PDF downloadLoading ...