The techniques to be described are concerned with the isolation and characterization of a nonhistone protein fraction from liver Iluclei.It is believed that all somatic cells possess the total genetic information characteristic of that organism.However, the mechanisms involved in the selective expression of this total information are unkllown.Stedman and Stedman' suggested that the histornes, the basic proteins of the nucleus, are involved in this control mechanism.It is, however, unlikely that the histones alone possess sufficient specificity for the coml)lete control of gene function,
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Alfred Gellhorn (1968) studied this question.