What question did this study set out to answer?

To determine whether early-stage lung cancer can be accurately identified through proteomic profiling of plasma biomarkers.

January 19, 2010CancerOpen Access

Elevated levels of the acute‐phase serum amyloid are associated with heightened lung cancer risk

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To determine whether early-stage lung cancer can be accurately identified through proteomic profiling of plasma biomarkers.
Analyzed plasma from an initial case-control cohort of 52 lung cancer patients and 51 controls using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.
Tested a four-marker proteomic classifier in a validation cohort of 16 patients with screen-detected lung cancer versus 406 healthy controls.
Identified the 11,681 m/z peak as serum amyloid A (SAA) and verified signal concentration relationships using enzyme-linked immunosorbent assay.
The four-marker classifier demonstrated 94.23% sensitivity and 76.47% specificity in the discovery cohort, but lost predictive performance in the validation group.
Across both cohorts combined, an SAA intensity ≥0.5 was strongly associated with lung cancer (OR 10.27, 95% CI 4.64–22.74).
In stage I disease, elevated SAA remained significantly predictive for both T1 (OR 8.45, 95% CI 2.76–25.83) and T2 tumors (OR 21.22, 95% CI 5.62–80.14).

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Implication

Case-control study shows elevated acute-phase serum amyloid A increases lung cancer risk, suggesting systemic inflammation contributes to early tumor development.

Cite This Study

Cremona et al. (2010) studied this question.

synapsesocial.com/papers/6a87b4ac514a20627548ee7b https://doi.org/10.1002/cncr.24868

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Implication

Case-control study shows elevated acute-phase serum amyloid A increases lung cancer risk, suggesting systemic inflammation contributes to early tumor development.

Elevated levels of the acute‐phase serum amyloid are associated with heightened lung cancer risk

Key Points

Discussion

Implication

Cite This Study

Elevated levels of the acute‐phase serum amyloid are associated with heightened lung cancer risk

Key Points

Discussion

Implication

Cite This Study

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