Wirt‐Gast‐Chemie, V. Verbesserte Synthesen makrocyclischer Azacyclophane – Temperatureffekte auf Ringgrößenverhältnisse bei der Cyclisierung

Host‐Guest Chemistry, V. Improved Syntheses of Macrocyclic Azacyclophanes – Temperature Effects on Ring Size Ratios in the Cyclisation The simplified reaction of (bis)tosylamides and α,ω‐dibromoalkanes using K 2 CO 3 in heterogeneous DMF solution as a deposit base allows to obtain large quantities of macrocycles ( 1 – 4 ) in 45 – 62% yields. The hitherto unknown temperature effect on the ratio of smaller to larger cyclophanes (diaza‐ to tetraaza rings, DR to TR) can be used to increase the DR/TR ratio, e.g. from 2.2 to > 28.